Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.56 |
| ▸ | HTR2A | P28223 | 8/20 | 0.52 |
| ▸ | DRD3 | P35462 | 8/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL706235 | 0.80 | HPGDS (0.59) | HPGDSHTR2ADRD3DRD2USP30 | |
| SCHEMBL5050050 | 0.78 | DRD3 (0.47) | HTR2ADRD3DRD2 | |
| SCHEMBL5051136 | 0.72 | MAPT (0.54) | HTR2ADRD3 | |
| SCHEMBL225392 | 0.72 | HTR2A (0.68) | HPGDSHTR2ADRD3DRD2 | |
| SCHEMBL229317 | 0.70 | HTR2A (0.69) | HPGDSHTR2ADRD3DRD2USP30 | |
| SCHEMBL357880 | 0.69 | USP30 (0.72) | HPGDSHTR2ADRD3DRD2USP30 | |
| SCHEMBL4193280 | 0.68 | HTR2A (1.00) | HTR2ADRD3 | |
| SCHEMBL604653 | 0.68 | HTR2A (1.00) | HTR2ADRD3 | |
| SCHEMBL29960440 | 0.66 | PARP1 (0.75) | PARP1 | |
| SCHEMBL29115541 | 0.66 | PARP1 (0.75) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | claimed |
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |