Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047842 | 0.88 | TRPV1 (0.46) | TRPV1ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL1856005 | 0.87 | TRPV1 (0.41) | TRPV1ALDH1A1HPGDHDAC3SPHK1 | |
| SCHEMBL5047479 | 0.86 | MAPK14 (0.47) | TRPV1ALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL1857834 | 0.78 | TRPV1 (0.44) | TRPV1ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL5044865 | 0.77 | TRPV1 (0.47) | TRPV1ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL4317777 | 0.76 | LSS (0.49) | TRPV1 | |
| SCHEMBL1859045 | 0.75 | STAT3 (0.46) | TRPV1ALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL5045568 | 0.75 | FOLH1 (0.46) | ALDH1A1HPGDTMEM97SIGMAR1SMN1; SMN2 | |
| SCHEMBL1856089 | 0.74 | EPHX2 (0.46) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6023278 | 0.73 | TRPV1 (0.53) | TRPV1ALDH1A1HPGDHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |