Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CFD | P00746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855554 | 0.85 | EPHX2 (0.45) | CHRM3EPHX2NR1H4TRPV1ROCK2 | |
| SCHEMBL5047546 | 0.85 | NPC1 (0.50) | EPHX2NR1H4GAA | |
| SCHEMBL5047990 | 0.85 | EPHX2 (0.51) | EPHX2NR1H4TRPV1TSHRCFD | |
| SCHEMBL5047048 | 0.82 | EPHX2 (0.41) | CHRM3EPHX2NR1H4TRPV1ROCK2 | |
| SCHEMBL5047823 | 0.78 | GAA (0.46) | CHRM3ROCK2ROCK1GAAKLKB1 | |
| SCHEMBL1855976 | 0.76 | EPHX2 (0.55) | EPHX2NR1H4TRPV1CFDSENP1 | |
| SCHEMBL11753901 | 0.75 | TSHR (0.69) | TSHRHSD17B10 | |
| SCHEMBL15562038 | 0.74 | EPHX2 (0.71) | CHRM3EPHX2NR1H4ROCK1CFD | |
| SCHEMBL1853253 | 0.74 | NAMPT (0.44) | GAAHDAC1 | |
| SCHEMBL1858105 | 0.74 | NAMPT (0.44) | GAAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |