Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KDM4B | O94953 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047742 | 0.85 | CHRM3 (0.47) | GAAEPHX2NR1H4 | |
| SCHEMBL1856432 | 0.85 | F10 (0.47) | NPC1RAB9AF10ALDH1A1HPGD | |
| SCHEMBL5047823 | 0.83 | GAA (0.46) | NPC1RAB9AMAPTSNCAGAA | |
| SCHEMBL6022596 | 0.83 | F10 (0.49) | NPC1RAB9AF10ALDH1A1HPGD | |
| SCHEMBL5044937 | 0.80 | F10 (0.44) | NPC1RAB9AF10ALDH1A1HPGD | |
| SCHEMBL1858105 | 0.75 | NAMPT (0.44) | NAMPTGAA | |
| SCHEMBL1853253 | 0.75 | NAMPT (0.44) | NAMPTGAA | |
| SCHEMBL1854548 | 0.75 | GAA (0.45) | NPC1RAB9AALDH1A1HPGDGAA | |
| SCHEMBL3900132 | 0.75 | RAB9A (0.63) | NPC1RAB9AF10NAMPTSNCA | |
| SCHEMBL5045301 | 0.75 | GAA (0.46) | NPC1RAB9AALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |