Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 4/20 | 0.71 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.71 |
| ▸ | FLT3 | P36888 | 3/20 | 0.71 |
| ▸ | AURKA | O14965 | 12/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.51 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CSK | P41240 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3428228 | 0.88 | FLT4 (0.74) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL5134262 | 0.87 | FLT4 (0.73) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2050465 | 0.86 | FLT4 (0.70) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3430686 | 0.86 | FLT4 (0.66) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3427462 | 0.86 | FLT4 (0.75) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2047693 | 0.85 | FLT4 (0.82) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3429390 | 0.85 | FLT4 (0.74) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2050139 | 0.85 | FLT4 (0.72) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3429103 | 0.84 | FLT4 (0.83) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL5489538 | 0.84 | AURKA (0.72) | FLT4PDGFRBFLT3AURKACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-B1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-03-26 | — | — | EP | disclosed |