Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4501169 | 0.86 | CCR1 (0.79) | CCR1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL3943460 | 0.81 | CCR1 (0.60) | CCR1SMN1; SMN2 | |
| SCHEMBL3946317 | 0.81 | CCR1 (0.78) | CCR1SMN1; SMN2ALDH1A1LMNAACE2 | |
| SCHEMBL16234873 | 0.75 | ALDH1A1 (0.61) | CCR1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL15164219 | 0.74 | CCR1 (0.79) | CCR1NPC1RAB9AMAPTALOX5 | |
| SCHEMBL4509271 | 0.74 | CCR1 (0.79) | CCR1SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL4486024 | 0.74 | CCR1 (1.00) | CCR1SMN1; SMN2ALDH1A1LMNAF2 | |
| SCHEMBL4490841 | 0.71 | CCR1 (0.74) | CCR1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL20639605 | 0.71 | KMT2A (0.49) | CCR1MAPTALDH1A1LMNAUSP2 | |
| SCHEMBL20639601 | 0.71 | KMT2A (0.49) | CCR1MAPTALDH1A1LMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973880-A1 | PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Brystol-Myers Squibb Company (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007087585-A1 | PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-02 | — | — | WO | disclosed |