Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044094 | 0.87 | CYP3A4 (0.38) | CYSLTR2CYSLTR1CYP3A4TSHRKCNH2 | |
| SCHEMBL6023224 | 0.81 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1CYP3A4TSHRCYP2C9 | |
| SCHEMBL5045111 | 0.80 | CYP3A4 (0.38) | CYSLTR2CYSLTR1CYP3A4TSHRKCNH2 | |
| SCHEMBL6022173 | 0.78 | DNM1 (0.35) | CYSLTR2CYSLTR1CYP3A4TSHRKCNH2 | |
| SCHEMBL6721375 | 0.78 | DNM1 (0.35) | CYSLTR2CYSLTR1CYP3A4TSHRKCNH2 | |
| SCHEMBL6721621 | 0.78 | CYP3A4 (0.40) | CYSLTR2CYSLTR1CYP3A4TSHRCYP2C9 | |
| SCHEMBL5047584 | 0.78 | MEN1 (0.42) | CYP2C9 | |
| SCHEMBL1852601 | 0.77 | CYSLTR2 (0.35) | CYSLTR2CYSLTR1CYP3A4TSHRKCNH2 | |
| SCHEMBL1852603 | 0.77 | CYP3A4 (0.35) | CYSLTR2CYSLTR1CYP3A4TSHRKCNH2 | |
| SCHEMBL6824407 | 0.77 | CYP3A4 (0.35) | CYSLTR2CYSLTR1CYP3A4TSHRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |