Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044011 | 0.96 | NR5A1 (0.42) | LMNAPPARGMAOBSLC2A1NR5A1 | |
| SCHEMBL5039923 | 0.91 | ACACB (0.45) | PPARGMAOBSLC2A1NR5A1FFAR1 | |
| SCHEMBL5044913 | 0.86 | HTR2A (0.43) | S1PR1S1PR4S1PR3S1PR5LMNA | |
| SCHEMBL17518295 | 0.79 | NR5A1 (0.59) | LMNACYP3A4NR5A1 | |
| SCHEMBL14382086 | 0.79 | NR5A1 (0.59) | LMNACYP3A4NR5A1 | |
| SCHEMBL5048886 | 0.79 | S1PR1 (0.51) | S1PR1S1PR4S1PR3S1PR5LMNA | |
| SCHEMBL28423723 | 0.78 | NR5A1 (0.56) | CYP3A4NR5A1 | |
| SCHEMBL5047701 | 0.77 | FFAR1 (0.47) | PPARGFFAR1 | |
| SCHEMBL5046558 | 0.77 | FFAR1 (0.47) | PPARGFFAR1 | |
| SCHEMBL5043877 | 0.76 | MAOB (0.43) | S1PR1S1PR4S1PR3S1PR5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |