Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 3/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047701 | 1.00 | FFAR1 (0.47) | FFAR1FFAR4MMP2MMP12TNK2 | |
| SCHEMBL5044417 | 1.00 | FFAR1 (0.47) | FFAR1FFAR4MMP2MMP12TNK2 | |
| SCHEMBL5045663 | 0.88 | FFAR1 (0.37) | FFAR1FFAR4SLC6A4HRH3ACACB | |
| SCHEMBL5046517 | 0.84 | FFAR1 (0.50) | FFAR1FFAR4MMP2MMP12TNK2 | |
| SCHEMBL5039923 | 0.84 | ACACB (0.45) | FFAR1ACACBPPARG | |
| SCHEMBL5044384 | 0.84 | PTGES2 (0.33) | FFAR1FFAR4KCNH2FFAR2PPARG | |
| SCHEMBL5044888 | 0.83 | ITGB1 (0.45) | FFAR1FFAR4MMP2MMP12ACACB | |
| SCHEMBL5044913 | 0.81 | HTR2A (0.43) | SLC6A4 | |
| SCHEMBL5048882 | 0.81 | HRH3 (0.37) | SLC6A4HRH3FFAR2 | |
| SCHEMBL6715158 | 0.81 | FFAR1 (0.49) | FFAR1FFAR4MMP2MMP12TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |