Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | SNCA | P37840 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049017 | 0.87 | MCHR1 (0.58) | MCHR1MEN1KMT2ARXFP1HIF1A | |
| SCHEMBL8163393 | 0.85 | MCHR1 (0.77) | MCHR1MEN1KMT2ARXFP1HIF1A | |
| SCHEMBL1854758 | 0.83 | MCHR1 (0.52) | MCHR1MEN1KMT2ARXFP1HIF1A | |
| SCHEMBL8162947 | 0.81 | HIF1A (0.72) | MCHR1MEN1KMT2AHIF1ANPC1 | |
| SCHEMBL10133038 | 0.80 | MEN1 (0.72) | MCHR1MEN1KMT2ARXFP1HIF1A | |
| SCHEMBL13073425 | 0.80 | HDAC2 (0.76) | MEN1KMT2ARXFP1HIF1ANPC1 | |
| SCHEMBL5039677 | 0.79 | NPC1 (0.68) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL8163396 | 0.77 | HSP90AA1 (0.68) | MCHR1MEN1KMT2ARXFP1HIF1A | |
| SCHEMBL6223646 | 0.77 | MCHR1 (0.77) | MCHR1MEN1KMT2ARXFP1HIF1A | |
| SCHEMBL1926318 | 0.76 | EPHX2 (0.77) | MEN1KMT2AHDAC1EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |