Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.77 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.75 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.75 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.75 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.75 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.75 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.75 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.75 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.75 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.75 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.73 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.73 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.69 |
| ▸ | MMP13 | P45452 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | CA1 | P00915 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226231 | 0.90 | HDAC6 (0.72) | EPHX2NR1H4HDAC1HDAC6HDAC2 | |
| SCHEMBL3461078 | 0.90 | HDAC6 (0.70) | EPHX2NR1H4HDAC1HDAC6HDAC3 | |
| SCHEMBL15764498 | 0.90 | ADAMTS5 (0.65) | EPHX2NR1H4HDAC1HDAC6HDAC3 | |
| SCHEMBL539059 | 0.89 | EPHX2 (0.84) | EPHX2NR1H4HDAC1HDAC6HDAC3 | |
| SCHEMBL8987867 | 0.88 | MEN1 (0.78) | EPHX2HDAC1HDAC6HDAC4HDAC7 | |
| SCHEMBL6386658 | 0.86 | HDAC6 (1.00) | EPHX2NR1H4HDAC1HDAC6HDAC3 | |
| SCHEMBL16712996 | 0.85 | ROCK2 (0.74) | MMP13RAB9AMEN1KMT2ASCN2A | |
| SCHEMBL8163393 | 0.85 | MCHR1 (0.77) | HDAC6HDAC2HDAC8ADAMTS5RAB9A | |
| SCHEMBL4981515 | 0.84 | EPHX2 (0.77) | EPHX2NR1H4HDAC1HDAC6HDAC3 | |
| SCHEMBL1927145 | 0.84 | EPHX2 (0.77) | EPHX2NR1H4HDAC1HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-B1 | ALPHA-HELICAL MIMETICS | WALTER & ELIZA HALL INST MEDICAL RES (AU) | 2018-02-21 | — | — | EP | disclosed |
| US-7956216-B2 | Benzoyl urea derivatives mimicing BH3-only proteins, able to interact with a Bcl-2 protein | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2011-06-07 | — | — | US | disclosed |
| US-20080153802-A1 | Alpha-helical mimetics | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2008-06-26 | — | — | US | disclosed |
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153802-A1 | Alpha-helical mimetics | BID, BAX, BAD | EPHX2 4035/4885NR1H4 1855/4885HDAC1 1665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.