Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 10/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5045806 | 0.91 | LMNA (0.66) | LMNATP53L3MBTL1TACR3 | |
| SCHEMBL4667483 | 0.86 | LMNA (0.55) | LMNATP53L3MBTL1TACR3CYP2C9 | |
| SCHEMBL5045993 | 0.83 | LMNA (0.66) | LMNATP53L3MBTL1TACR3 | |
| SCHEMBL4667486 | 0.82 | LMNA (0.52) | LMNATP53L3MBTL1TACR3CYP2C9 | |
| SCHEMBL4667525 | 0.82 | LMNA (0.50) | LMNATP53L3MBTL1TACR3CYP2C9 | |
| SCHEMBL4667111 | 0.81 | LMNA (0.49) | LMNATP53L3MBTL1TACR3CYP2C9 | |
| SCHEMBL4667053 | 0.81 | TACR3 (0.55) | LMNATACR3 | |
| SCHEMBL4961957 | 0.81 | TACR3 (0.51) | LMNAL3MBTL1TACR3CYP2C9 | |
| SCHEMBL5046700 | 0.78 | LMNA (0.61) | LMNATP53L3MBTL1TACR3 | |
| SCHEMBL4962172 | 0.78 | TACR3 (0.50) | LMNAL3MBTL1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928835-A1 | ALKYL SULFOXIDE QUINOLINES AS NK-3 RECEPTOR LIGANDS | Astra Zeneca AB (SE) | 2008-06-11 | — | — | EP | claimed |
| WO-2007035158-A1 | ALKYL SULFOXIDE QUINOLINES AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | claimed |