Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPY2R | P49146 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508912 | 0.89 | NPSR1 (0.45) | NPSR1KMT2ALMNAMAPTNPY2R | |
| Trifluoroacetic Acid SCHEMBL4508906 | 0.79 | CCR1 (0.58) | NPSR1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL13606408 | 0.76 | CCR1 (0.64) | NPSR1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL4501202 | 0.71 | NPSR1 (0.48) | NPSR1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL4501206 | 0.71 | NPSR1 (0.48) | NPSR1KMT2ALMNAMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL4502717 | 0.70 | NPSR1 (0.48) | NPSR1KMT2ALMNAMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL4502722 | 0.70 | NPSR1 (0.48) | NPSR1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL15164229 | 0.69 | KMT2A (0.59) | NPSR1KMT2ALMNAMAPTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5444922 | 0.68 | LMNA (0.47) | NPSR1KMT2ALMNAALDH1A1MC4R | |
| Trifluoroacetic Acid SCHEMBL5444973 | 0.68 | KMT2A (0.52) | NPSR1KMT2ALMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973880-A1 | PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Brystol-Myers Squibb Company (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007087585-A1 | PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-02 | — | — | WO | disclosed |