SCHEMBL5049534

SCHEMBL5049534

COc1cc2c(Oc3ccc(NC(=O)N4CCN(c5ccccc5)C4=O)cc3F)ccnc2cc1OCC1CCN(C(=O)O)CC1

nearest known ligand 0.89

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.89
KDR P35968 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5107976 0.94 MET (1.00) METKDR
SCHEMBL5107581 0.93 MET (0.83) METKDR
SCHEMBL5050741 0.92 MET (1.00) METKDR
SCHEMBL5094665 0.90 MET (1.00) METKDR
SCHEMBL5056188 0.85 MET (1.00) METKDR
SCHEMBL5107654 0.84 MET (1.00) METKDR
SCHEMBL5050783 0.84 MET (1.00) METKDR
SCHEMBL5054203 0.83 MET (1.00) METKDR
SCHEMBL5101770 0.83 MET (1.00) METKDR
SCHEMBL198697 0.82 MET (0.74) METKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008035209-A2 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY METHYLGENE INC. (CA) 2008-03-27 WO disclosed