Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPRB | P23467 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857304 | 0.87 | PTPN2 (0.48) | PKMPTPN2PTPRBPTPN6PTK2 | |
| SCHEMBL12213152 | 0.85 | PTK2 (0.59) | PKMPTK2NPC1RAB9APPARG | |
| SCHEMBL765316 | 0.83 | SMN1; SMN2 (0.56) | PKMPTK2NPC1RAB9APPARG | |
| SCHEMBL11777129 | 0.83 | GSK3B (0.43) | PKMPTPN2PTPRBPTPN6PTK2 | |
| SCHEMBL7748143 | 0.81 | MAPK10 (0.65) | NPC1RAB9ASMN1; SMN2HPGDMAPK10 | |
| SCHEMBL8090363 | 0.80 | MAPT (0.43) | PKMNPC1RAB9AGSK3BHPGD | |
| SCHEMBL1380571 | 0.79 | TGM2 (0.49) | PKMNPC1RAB9APPARGNCOR2 | |
| SCHEMBL6716911 | 0.78 | PTK2 (0.35) | PKMPTPN2PTPRBPTPN6PTK2 | |
| SCHEMBL14218016 | 0.77 | PTPN1 (0.50) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL2928945 | 0.77 | CA12 (0.45) | NPC1RAB9ASMN1; SMN2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102633783-A | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA INC | 2012-08-15 | — | — | CN | disclosed |
| CN-101379060-B | Benzoxazole-based derivatives as Aurora kinase inhibitors, compositions, and methods of use | TRANSTECH PHARMA INC | 2012-05-23 | — | — | CN | disclosed |
| CN-101379060-A | Benzoxazole-based derivatives as Aurora kinase inhibitors, compositions, and methods of use | TRANSTECH PHARMA INC (US) | 2009-03-04 | — | — | CN | disclosed |
| EP-1987028-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | Transtech Pharma, Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007095124-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |
| CN-1269793-A | Pyrimidin-2-oxo-4-one and pyrimidin-2-oxo-4-thione derivatives | NOVARTIS AG (CH) | 2000-10-11 | — | — | CN | disclosed |