Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | FLT1 | P17948 | 3/20 | 0.37 |
| ▸ | FLT4 | P35916 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390818 | 0.84 | GPR119 (0.59) | GPR119 | |
| SCHEMBL3167373 | 0.82 | GPR119 (0.49) | GPR119 | |
| SCHEMBL6065464 | 0.80 | GPR119 (0.44) | GPR119EGFRFGFR1FLT1FLT4 | |
| SCHEMBL5048834 | 0.78 | GPR119 (0.54) | GPR119 | |
| SCHEMBL5052397 | 0.76 | GPR119 (0.51) | GPR119EGFRFGFR1FLT1FLT4 | |
| SCHEMBL5048756 | 0.74 | GPR119 (0.67) | GPR119EGFRFGFR1FLT1FLT4 | |
| SCHEMBL391562 | 0.70 | GPR119 (0.61) | GPR119 | |
| SCHEMBL3164053 | 0.68 | GPR119 (0.50) | GPR119 | |
| SCHEMBL13022148 | 0.68 | GPR119 (0.65) | GPR119 | |
| SCHEMBL5190095 | 0.68 | GPR119 (0.37) | GPR119EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120702-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |