Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NMT1 | P30419 | 2/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 4/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390173 | 0.87 | PRKCI (0.39) | PIK3CAPIK3R1NMT1MTORPRKCI | |
| Hydrochloric Acid SCHEMBL4529967 | 0.86 | PRKCI (0.39) | PIK3CAPIK3R1NMT1MTORPRKCI | |
| SCHEMBL387027 | 0.83 | PIK3CA (0.47) | PIK3CAPIK3R1SIRT2SIRT1SIRT3 | |
| Hydrochloric Acid SCHEMBL4518127 | 0.79 | RORC (0.41) | PIK3CAMTORPRKCIPDE4B | |
| SCHEMBL391776 | 0.79 | PDE4A (0.44) | PIK3CAPIK3R1KDM4ERAF1BRAF | |
| Hydrochloric Acid SCHEMBL4518915 | 0.78 | PDE4A (0.43) | PIK3CAPIK3R1KDM4ERAF1BRAF | |
| SCHEMBL390178 | 0.78 | MPL (0.40) | PIK3CAKDM4ENPSR1LMNARAF1 | |
| SCHEMBL390254 | 0.78 | PRKCI (0.40) | PIK3CAPIK3R1RAF1BRAFMTOR | |
| Hydrochloric Acid SCHEMBL4508182 | 0.77 | PRKCI (0.39) | PIK3CAPIK3R1RAF1BRAFMTOR | |
| Hydrochloric Acid SCHEMBL4518145 | 0.77 | MPL (0.39) | PIK3CAKDM4ENPSR1LMNARAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120702-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |