Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | CPT2 | P23786 | 1/20 | 0.30 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1276399 | 0.96 | ALDH1A1 (0.42) | ALDH1A1 | |
| Demannose SCHEMBL6062262 | 0.91 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL1774085 | 0.85 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL290076 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4ECPT2ACLYLMNA | |
| SCHEMBL18585615 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4ECPT2ACLYLMNA | |
| SCHEMBL1079363 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4ECPT2ACLYLMNA | |
| SCHEMBL2226410 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4ECPT2ACLYLMNA | |
| SCHEMBL14423955 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4ECPT2ACLYLMNA | |
| SCHEMBL5355291 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4ECPT2ACLYLMNA | |
| SCHEMBL18585528 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4ECPT2ACLYLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1941063-A1 | SEPARATION PROCESS | DANISCO A/S (DK) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007048880-A1 | SEPARATION PROCESS | DANISCO A/S (DK) | 2007-05-03 | — | — | WO | disclosed |