Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Diphenylmethanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylmethanol SCHEMBL28193469 | 0.92 | LMNA (0.61) | LMNASMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| Diphenylmethanol SCHEMBL10868602 | 0.86 | SMN1; SMN2 (0.61) | LMNASMN1; SMN2L3MBTL1KDM4EADRA2A | |
| Diphenylmethanol SCHEMBL41571 | 0.86 | SMN1; SMN2 (0.61) | LMNASMN1; SMN2L3MBTL1KDM4EADRA2A | |
| Diphenylmethanol SCHEMBL11564700 | 0.86 | SMN1; SMN2 (0.61) | LMNASMN1; SMN2L3MBTL1KDM4EADRA2A | |
| Diphenylmethanol SCHEMBL6434457 | 0.86 | SMN1; SMN2 (0.61) | LMNASMN1; SMN2L3MBTL1KDM4EADRA2A | |
| Diphenylmethanol SCHEMBL11393715 | 0.83 | LMNA (0.52) | LMNASMN1; SMN2L3MBTL1KDM4EATM | |
| Diphenylmethanol SCHEMBL9324200 | 0.83 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2L3MBTL1KDM4EADRA2A | |
| Diphenylmethanol SCHEMBL8164003 | 0.83 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2L3MBTL1KDM4EADRA2A | |
| Diphenylmethanol SCHEMBL15641329 | 0.83 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2L3MBTL1KDM4EADRA2A | |
| SCHEMBL8671295 | 0.83 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2L3MBTL1KDM4EADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4736015-A | FROM DI-(ORTETRA) ESTER OF BENZHYDROL 3,3*,4,4*-TETRACARBOXYLIC ACID AND AROMATIC DIAMINE | INSTITUT FRANCAIS DU PETROLE (FR) | 1988-04-05 | — | — | US | claimed |
| EP-1873156-A1 | Process for the preparation of 6-[[(alkoxy)carbonyl]amino]-9H-Purine-9-acetic acid and 4-[(alkoxycarbonyl)amino]-2-oxo-1(2H)-Pyrimidineacetic acid derivatives as synthons for the synthesis of peptide nucleic acids | PerSeptive Biosystems, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-0736027-B1 | GUANINE SYNTHONS FOR PEPTIDE NUCLEIC ACID SYNTHESIS AND METHOD FOR PRODUCTION | PERSEPTIVE BIOSYSTEMS INC (US) | 2002-05-29 | — | — | EP | disclosed |
| US-6172226-B1 | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions | PERSEPTIVE BIOSYSTEMS, INC. | 2001-01-09 | — | — | US | disclosed |
| EP-0840736-A1 | IMPROVED SYNTHONS FOR THE SYNTHESIS AND DEPROTECTION OF PEPTIDE NUCLEIC ACIDS UNDER MILD CONDITIONS | PerSeptive Biosystems, Inc. (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1996040685-A1 | IMPROVED SYNTHONS FOR THE SYNTHESIS AND DEPROTECTION OF PEPTIDE NUCLEIC ACIDS UNDER MILD CONDITIONS | PERSEPTIVE BIOSYSTEMS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0736027-A1 | GUANINE SYNTHONS FOR PEPTIDE NUCLEIC ACID SYNTHESIS AND METHOD FOR PRODUCTION | PERSEPTIVE BIOSYSTEMS, INC. (US) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017403-A1 | GUANINE SYNTHONS FOR PEPTIDE NUCLEIC ACID SYNTHESIS AND METHOD FOR PRODUCTION | PERSEPTIVE BIOSYSTEMS, INC. (US) | 1995-06-29 | — | — | WO | disclosed |