Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 11/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.32 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835087 | 0.84 | BRD4 (0.34) | BRD4CREBBPNR1H2ATRATRIP | |
| SCHEMBL5046934 | 0.84 | BRD4 (0.37) | BRD4CREBBPNR1H2NR1H3CA12 | |
| SCHEMBL27700249 | 0.83 | BRD4 (0.34) | BRD4CREBBPNR1H2ATRATRIP | |
| SCHEMBL3048125 | 0.82 | NR1H2 (0.37) | BRD4CREBBPNR1H2ATRATRIP | |
| SCHEMBL3044227 | 0.81 | BRD4 (0.39) | BRD4CREBBPNR1H2ATRATRIP | |
| SCHEMBL3034386 | 0.81 | BRD4 (0.51) | BRD4CREBBPNR1H2NR1H3CA12 | |
| SCHEMBL3043890 | 0.81 | BRD4 (0.38) | BRD4CREBBPNR1H2ATRATRIP | |
| SCHEMBL3041891 | 0.80 | NR1H2 (0.38) | BRD4CREBBPNR1H2ATRATRIP | |
| SCHEMBL3047590 | 0.80 | NR1H2 (0.45) | BRD4CREBBPNR1H2ATRATRIP | |
| SCHEMBL3047581 | 0.80 | NR1H2 (0.34) | BRD4CREBBPNR1H2ATRATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915372-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | Merck Frosst Canada Ltd. (CA) | 2008-04-30 | — | — | EP | disclosed |
| EP-1880993-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-01-23 | — | — | EP | disclosed |
| WO-2007019675-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA LTD. (CA) | 2007-02-22 | — | — | WO | disclosed |