Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 4/20 | 0.51 |
| ▸ | MMP2 | P08253 | 4/20 | 0.51 |
| ▸ | MMP9 | P14780 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL505068 | 1.00 | MEN1 (0.68) | MEN1KMT2ACYP1A2NPSR1HTT | |
| SCHEMBL10212303 | 1.00 | MEN1 (0.68) | MEN1KMT2ACYP1A2NPSR1HTT | |
| SCHEMBL27296620 | 0.83 | HTT (0.59) | MEN1KMT2ACYP1A2NPSR1HTT | |
| SCHEMBL183793 | 0.81 | MEN1 (1.00) | MEN1KMT2ACYP1A2NPSR1NPC1 | |
| SCHEMBL183747 | 0.81 | MEN1 (1.00) | MEN1KMT2ACYP1A2NPSR1NPC1 | |
| SCHEMBL505845 | 0.81 | MEN1 (0.68) | MEN1KMT2ACYP1A2NPSR1NPC1 | |
| SCHEMBL505846 | 0.81 | MEN1 (0.68) | MEN1KMT2ACYP1A2NPSR1NPC1 | |
| SCHEMBL505530 | 0.81 | MEN1 (0.68) | MEN1KMT2ACYP1A2NPSR1NPC1 | |
| SCHEMBL183746 | 0.81 | MEN1 (1.00) | MEN1KMT2ACYP1A2NPSR1NPC1 | |
| SCHEMBL733110 | 0.81 | NPSR1 (0.56) | MEN1KMT2ACYP1A2NPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| CN-102898402-A | Benzisoselenazolone-modified pyrrolyl formate-substituted indolone compound and use thereof | UNIV BEIJING | 2013-01-30 | — | — | CN | disclosed |
| EP-2414328-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Merck Serono S.A. (CH) | 2012-02-08 | — | — | EP | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
| WO-2010115736-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-10-14 | — | — | WO | disclosed |
| EP-0030424-B1 | DERIVATIVES OF 4-(METHYLPHOSPHINYL)-2-OXOBUTANOIC ACID, HERBICIDAL COMPOSITIONS CONTAINING THEM, AND INTERMEDIATES AND METHODS FOR THEIR PRODUCTION | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-02-20 | — | — | EP | disclosed |
| US-4399287-A | POSTEMERGENCE HERBICIDES; PESTICIDES; PLANT GROWTH REGULATORS; DESICCANTS | FBC LIMITED (GB) | 1983-08-16 | — | — | US | disclosed |
| EP-0009348-B1 | PESTICIDALLY ACTIVE SALTS AND COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR MANUFACTURE AND USE | FBC LIMITED (GB) | 1983-07-20 | — | — | EP | disclosed |
| EP-0026034-B1 | 5-AMINO-4-CYANO-1-(2,4,6-TRICHLOROPHENYL)PYRAZOLE, PROCESS FOR ITS PREPARATION, HERBICIDAL COMPOSITIONS CONTAINING IT AND THEIR USE | FBC LIMITED (GB) | 1983-03-23 | — | — | EP | disclosed |
| US-4364769-A | PREEMERGENCE, POSTEMERGENCE HERBICIDES | CIBA-GEIGY CORPORATION (US) | 1982-12-21 | — | — | US | disclosed |
| EP-0026034-A1 | 5-Amino-4-cyano-1-(2,4,6-trichlorophenyl)pyrazole, process for its preparation, herbicidal compositions containing it and their use | FBC LIMITED (GB) | 1981-04-01 | — | — | EP | disclosed |
| WO-1981000665-A1 | PLANT PHYSIOLOGICALLY ACTIVE COMPOSITION AND USE | FISONS LTD (GB) | 1981-03-19 | — | — | WO | disclosed |
| EP-0024841-A1 | Plant physiologically active composition and use | FBC LIMITED (GB) | 1981-03-11 | — | — | EP | disclosed |
| EP-0022750-A1 | 1,3,4-Thiadiazolyloxy-phenyl ureas, their preparation and herbicides containing them | CIBA-GEIGY AG (CH) | 1981-01-21 | — | — | EP | disclosed |
| EP-0010396-A1 | Fungicidal and herbicidal compositions, certain cyanomethane and cyanoethene derivatives being active agents thereof, the preparation of these derivatives and methods for combating fungi and weeds | FBC LIMITED (GB) | 1980-04-30 | — | — | EP | disclosed |
| EP-0009348-A2 | Pesticidally active salts and compositions containing them and processes for their manufacture and use | FBC LIMITED (GB) | 1980-04-02 | — | — | EP | disclosed |
| EP-0008506-A2 | Herbicidal heterocyclic compounds and compositions and methods for their use | FBC LIMITED (GB) | 1980-03-05 | — | — | EP | disclosed |
| EP-0007719-A2 | Cyanbenzofuran derivatives, processes for their preparation and their use in herbicidal compositions; cyanobenzene, benzodioxepine, benzodioxaphosphepine and benzodioxathiepine derivatives | FBC LIMITED (GB) | 1980-02-06 | — | — | EP | disclosed |
| EP-0006681-A1 | Herbicidal composition and method | FISONS plc (GB) | 1980-01-09 | — | — | EP | disclosed |
| EP-0002881-A1 | 5-Isoxazolylurea derivatives, their preparation, their use and compositions containing them | FISONS plc (GB) | 1979-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, FH, DPYD | MEN1 1133/4885KMT2A 836/4885CYP1A2 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.