SCHEMBL5050864

SCHEMBL5050864

Cc1c(Oc2ccc(S(C)(=O)=O)cn2)ncnc1OC1CCNCC1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.44
CYP2C9 P11712 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27734886 0.82 GPR119 (0.37) GPR119
SCHEMBL1890890 0.81 GPR119 (0.66) GPR119CYP2C9
Hydrochloric Acid SCHEMBL1895317 0.80 GPR119 (0.65) GPR119CYP2C9
SCHEMBL385911 0.79 GPR119 (0.73) GPR119CYP2C9
SCHEMBL3164501 0.77 GPR119 (0.57) GPR119CYP2C9
Hydrochloric Acid SCHEMBL14634431 0.77 GPR119 (0.59) GPR119
Hydrochloric Acid SCHEMBL2557741 0.77 GPR119 (0.59) GPR119
SCHEMBL16384798 0.77 GPR119 (0.43) GPR119CYP2C9
SCHEMBL12236467 0.77 HRH1 (0.43) GPR119
SCHEMBL3816276 0.75 GPR119 (0.41) GPR119CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2004157-A2 USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO Arena Pharmaceuticals, Inc. (US) 2008-12-24 EP disclosed
WO-2007120702-A2 USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO ARENA PHARMACEUTICALS, INC. (US) 2007-10-25 WO disclosed