Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.56 |
| ▸ | BLK | P51451 | 2/20 | 0.56 |
| ▸ | STK3 | Q13188 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.56 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.56 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.56 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5056467 | 0.93 | BRAF (0.56) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL5054944 | 0.93 | KDR (0.62) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL5062541 | 0.90 | MAPK14 (0.54) | KDRROCK2RETAURKBFLT1 | |
| SCHEMBL5054928 | 0.90 | KDR (0.60) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL5056699 | 0.90 | KDR (0.59) | KDRROCK2RETAURKBFLT1 | |
| SCHEMBL5056268 | 0.88 | PTK2 (0.60) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL2085188 | 0.86 | KDR (0.52) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL5052388 | 0.86 | ABL1 (0.65) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL5052336 | 0.86 | MAPK13 (0.55) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL5060643 | 0.85 | KDR (0.64) | KDRROCK2MAP4K4LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | ABL2, BRAF, MAP3K1 | KDR 41/4885ROCK2 287/4885MAP4K4 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.