Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048788 | 0.88 | MAPT (0.42) | LMNASMN1; SMN2MAPTKMT2AFAAH | |
| SCHEMBL1457699 | 0.80 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL5120134 | 0.75 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL1457183 | 0.70 | HCRTR1 (0.42) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL1457630 | 0.68 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL1457254 | 0.67 | LMNA (0.40) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL1457068 | 0.67 | MEN1 (0.40) | MAPTKMT2AMEN1POLB | |
| SCHEMBL1457755 | 0.66 | PDGFRB (0.43) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL5054621 | 0.66 | EPHX1 (0.39) | LMNASMN1; SMN2KMT2AALDH1A1GAA | |
| SCHEMBL1457132 | 0.65 | PDGFRB (0.43) | SMN1; SMN2MAPTKMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893620-A2 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF DRUGS | Grünenthal GmbH (DE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006122769-A2 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF DRUGS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |