Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitazoxanide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 8/20 | 1.00 |
| ▸ | NPC1 | O15118 | 8/20 | 1.00 |
| ▸ | RAB9A | P51151 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | PKM | P14618 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | MLNR | O43193 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitazoxanide SCHEMBL40981 | 1.00 | STAT3 (1.00) | STAT3NPC1RAB9AMEN1KMT2A | |
| Nitazoxanide SCHEMBL29373905 | 1.00 | STAT3 (1.00) | STAT3NPC1RAB9AMEN1KMT2A | |
| Nitazoxanide SCHEMBL28195534 | 0.99 | STAT3 (0.98) | STAT3NPC1RAB9AMEN1KMT2A | |
| Nitazoxanide SCHEMBL27651337 | 0.99 | STAT3 (0.98) | STAT3NPC1RAB9AMEN1KMT2A | |
| Nitazoxanide SCHEMBL19512160 | 0.97 | STAT3 (0.94) | STAT3NPC1RAB9AMEN1KMT2A | |
| Nitazoxanide SCHEMBL28333130 | 0.95 | STAT3 (0.90) | STAT3NPC1RAB9AMEN1KMT2A | |
| Nitazoxanide SCHEMBL19449896 | 0.92 | STAT3 (0.86) | STAT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL16572481 | 0.91 | NPC1 (0.83) | STAT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL29056942 | 0.91 | STAT3 (0.83) | STAT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL30142740 | 0.90 | MEN1 (0.82) | STAT3NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675838-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | Puretecch LYT, Inc. (US) | 2020-07-08 | — | — | EP | disclosed |
| WO-2019046491-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | ARIYA THERAPEUTICS, INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| CN-105777808-A | Tizoxanide phosphate and alkyl sulfonate and applications thereof in pharmacy | 中国人民解放军军事医学科学院毒物药物研究所 | 2016-07-20 | — | — | CN | disclosed |
| EP-1931760-A2 | MULTI-FUNCTIONAL IONIC LIQUID COMPOSITIONS | The University of Alabama (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007044693-A2 | MULTI-FUNCTIONAL IONIC LIQUID COMPOSITIONS | THE UNIVERSITY OF ALABAMA (US) | 2007-04-19 | — | — | WO | disclosed |