Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5052179 | 0.94 | KDR (0.54) | KDRMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5054994 | 0.91 | KDR (0.53) | KDRMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5054766 | 0.89 | KDR (0.45) | KDRMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5052411 | 0.89 | KDR (0.51) | KDRMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5055155 | 0.88 | ABL1 (0.49) | KDRMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5052081 | 0.87 | KDR (0.46) | KDRMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5054874 | 0.87 | KDR (0.52) | KDRMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5062437 | 0.86 | ABL1 (0.48) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL5542477 | 0.85 | KDR (0.51) | KDRMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5056467 | 0.84 | BRAF (0.56) | KDRMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | ABL2, BRAF, MAP3K1 | KDR 41/4885MAPK14 100/4885MAPK13 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.