Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.48 |
| ▸ | BLK | P51451 | 2/20 | 0.48 |
| ▸ | STK3 | Q13188 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.48 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2072949 | 0.92 | KDR (0.48) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL5052179 | 0.91 | KDR (0.54) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL5054994 | 0.89 | KDR (0.53) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL2082144 | 0.87 | KDR (0.53) | KDRROCK2MAP4K4LCKRET | |
| Hydrochloric Acid SCHEMBL2082034 | 0.86 | KDR (0.53) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL5060551 | 0.85 | KDR (0.53) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL5056378 | 0.85 | KDR (0.47) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL2085188 | 0.85 | KDR (0.52) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL2084628 | 0.84 | KDR (0.48) | KDRROCK2MAP4K4LCKRET | |
| SCHEMBL2081755 | 0.83 | KDR (0.47) | KDRROCK2MAP4K4LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1835934-A2 | ENZYME MODULATORS AND TREATMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006071940-A2 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-07-06 | — | — | WO | disclosed |