Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PGD | P52209 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.31 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300984 | 0.81 | SLC22A6 (0.39) | SLC22A6SMN1; SMN2MAPTGABRR1LMNA | |
| SCHEMBL1300672 | 0.79 | ALDH1A1 (0.37) | SLC22A6SMN1; SMN2LMNAGPR84 | |
| SCHEMBL1300069 | 0.75 | SMN1; SMN2 (0.48) | SLC22A6SMN1; SMN2MAPTGABRR1LMNA | |
| SCHEMBL28026299 | 0.73 | SMN1; SMN2 (0.52) | SLC22A6SMN1; SMN2PGDMAPTGABRR1 | |
| SCHEMBL28026256 | 0.71 | SMN1; SMN2 (0.50) | SLC22A6SMN1; SMN2MAPTGABRR1LMNA | |
| SCHEMBL28026786 | 0.71 | SMN1; SMN2 (0.50) | SLC22A6SMN1; SMN2MAPTGABRR1LMNA | |
| SCHEMBL4488636 | 0.71 | SLC22A6 (0.42) | SLC22A6SMN1; SMN2MAPTGABRR1LMNA | |
| Ammonia Solution, Strong SCHEMBL28026257 | 0.71 | SMN1; SMN2 (0.50) | SLC22A6SMN1; SMN2MAPTGABRR1LMNA | |
| SCHEMBL5077944 | 0.71 | SLC22A6 (0.50) | SLC22A6SMN1; SMN2MAPTGABRR1LMNA | |
| SCHEMBL304303 | 0.71 | SLC22A6 (0.50) | SLC22A6SMN1; SMN2MAPTGABRR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080300208-A1 | Isociatrate dehydrogenase and uses therof | QUARK PHARMACEUTICALS, INC. | 2008-12-04 | — | — | US | claimed |
| US-20040067234-A1 | Isocitrate dehydrogenase and uses thereof | QUARK PHARMACUTICALS, INC. | 2004-04-08 | — | — | US | claimed |
| US-20080300208-A1 | Isociatrate dehydrogenase and uses therof | QUARK PHARMACEUTICALS, INC. | 2008-12-04 | — | — | US | disclosed |
| US-20040067234-A1 | Isocitrate dehydrogenase and uses thereof | QUARK PHARMACUTICALS, INC. | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067234-A1 | Isocitrate dehydrogenase and uses thereof | IDH2, IDH1, IDH3A | SLC22A6 1815/4885SMN1; SMN2 2214/4885PGD 726/4885 |
| US-20080300208-A1 | Isociatrate dehydrogenase and uses therof | IDH2, IDH1, IDH3A | SLC22A6 2136/4885SMN1; SMN2 1014/4885PGD 400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.