Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054968 | 1.00 | CYP1A2 (0.45) | CYP1A2CYP2C19CYP2C9RAB9ANPC1 | |
| SCHEMBL5051501 | 1.00 | CYP1A2 (0.45) | CYP1A2CYP2C19CYP2C9RAB9ANPC1 | |
| SCHEMBL5053735 | 1.00 | CYP1A2 (0.45) | CYP1A2CYP2C19CYP2C9RAB9ANPC1 | |
| SCHEMBL5060776 | 0.92 | IDO1 (0.47) | MAPTSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL5051502 | 0.91 | ALDH1A1 (0.49) | CYP1A2CYP2C19CYP2C9RAB9ANPC1 | |
| SCHEMBL5058334 | 0.91 | ALDH1A1 (0.49) | CYP1A2CYP2C19CYP2C9RAB9ANPC1 | |
| SCHEMBL5051524 | 0.90 | MAPT (0.49) | MAPTSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL12797211 | 0.90 | MAPT (0.49) | MAPTSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL5053666 | 0.89 | SMN1; SMN2 (0.49) | MAPTSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL5053688 | 0.89 | SMN1; SMN2 (0.49) | MAPTSMN1; SMN2KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897764-B2 | Thiourea derivatives | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-03-01 | — | — | US | disclosed |
| US-7897764-B2 | Thiourea derivatives | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-03-01 | — | — | US | disclosed |
| US-7897764-B2 | Thiourea derivatives | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-03-01 | — | — | US | disclosed |
| WO-2008154091-A1 | THIOUREA DERIVATIVES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-12-18 | — | — | WO | disclosed |
| US-20080306090-A1 | THIOUREA DERIVATIVES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-12-11 | — | — | US | disclosed |
| US-20080306090-A1 | THIOUREA DERIVATIVES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-12-11 | — | — | US | disclosed |
| US-20080306090-A1 | THIOUREA DERIVATIVES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306090-A1 | THIOUREA DERIVATIVES | EIF2AK2, IFNAR1, TPMT | CYP1A2 423/4885CYP2C19 1381/4885CYP2C9 643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.