Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.57 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.56 |
| ▸ | ALKBH3 | Q96Q83 | 10/20 | 0.52 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.48 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | FPR1 | P21462 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178964 | 0.76 | KAT8 (0.76) | KDM4EKAT8ALKBH3MT-CO1MT-CO2 | |
| SCHEMBL28469187 | 0.75 | KDM4E (0.60) | KDM4EKAT8ALKBH3MT-CO1MT-CO2 | |
| SCHEMBL28472265 | 0.75 | KDM4E (0.60) | KDM4EKAT8ALKBH3MT-CO1MT-CO2 | |
| SCHEMBL28300564 | 0.74 | KAT8 (0.72) | KDM4EKAT8ALKBH3MT-CO1MT-CO2 | |
| SCHEMBL2571554 | 0.73 | KDM4E (1.00) | KDM4EKAT8ALKBH3TDP1POLB | |
| SCHEMBL7546021 | 0.73 | CYP1A2 (0.56) | KDM4EKAT8ALKBH3MT-CO1MT-CO2 | |
| SCHEMBL28475283 | 0.73 | MT-CO1 (0.69) | KDM4EKAT8ALKBH3MT-CO1MT-CO2 | |
| SCHEMBL28477954 | 0.72 | KAT8 (0.65) | KDM4EKAT8ALKBH3MT-CO1MT-CO2 | |
| SCHEMBL28477726 | 0.72 | PARP14 (0.70) | KDM4EKAT8ALKBH3MT-CO1MT-CO2 | |
| SCHEMBL28300562 | 0.71 | KAT8 (0.60) | KDM4EKAT8ALKBH3MT-CO1MT-CO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924562-A2 | PYRAZOLONE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025880-A2 | PYRAZOLONE DERIVATIVES AS 11-BETA HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |