MT-CO1

Cytochrome c oxidase subunit 1 · P00395 · MT-CO1 on Sugi Atlas →

1,084 patent compounds predicted against MT-CO1, 764 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2305708 SCHEMBL2305708 0.47 3/20
SCHEMBL2912218 SCHEMBL2912218 0.46 3/20
SCHEMBL486229 SCHEMBL486229 0.45 3/20
SCHEMBL19449219 SCHEMBL19449219 1.00 2/20
SCHEMBL19449242 SCHEMBL19449242 1.00 2/20
SCHEMBL19449235 SCHEMBL19449235 0.85 2/20
SCHEMBL19449240 SCHEMBL19449240 0.84 2/20
SCHEMBL19449244 SCHEMBL19449244 0.76 2/20
SCHEMBL19449217 SCHEMBL19449217 0.75 2/20
SCHEMBL19449277 SCHEMBL19449277 0.75 2/20
SCHEMBL19449238 SCHEMBL19449238 0.72 2/20
SCHEMBL19449245 SCHEMBL19449245 0.69 2/20
SCHEMBL19449224 SCHEMBL19449224 0.69 2/20
SCHEMBL19449212 SCHEMBL19449212 0.64 2/20
SCHEMBL19449247 SCHEMBL19449247 0.61 2/20
SCHEMBL19449246 SCHEMBL19449246 0.60 2/20
SCHEMBL19449213 SCHEMBL19449213 0.59 2/20
SCHEMBL19449226 SCHEMBL19449226 0.58 2/20
SCHEMBL2657553 SCHEMBL2657553 0.56 2/20
SCHEMBL3032146 SCHEMBL3032146 0.56 2/20

Clinical trials — most relevant to MT-CO1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
The KHENEREXT Study PHASE2COMPLETED
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) PHASE1/PHASE2NOT_YET_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome nanCOMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Red Light Ptosis Proof-of-Concept nanUNKNOWN
The Natural History of Mitochondrial Diseases nanRECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity nanRECRUITING
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
The Genetics of Diabetes in Southern California Chinese Americans nanWITHDRAWN
Ccf mtDNA as a Neurodegenerative Biomarker nanUNKNOWN
Diagnostic Odyssey Survey 2 nanCOMPLETED
Mitochondrial nt3243 A>G Mutation in Taiwan nanUNKNOWN
Survey on Supplement Use in Mitochondrial Disease nanCOMPLETED
Natural History in Primary Mitochondrial Myopathies nanRECRUITING
Mitoquines in COPD nanUNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
Natural History Study - Mitochondrial Disease nanRECRUITING
Cardiac Mitochondrial Function in Explanted Human Hearts nanUNKNOWN
Paediatric Obesity and Cardiovascular Dysfunction nanCOMPLETED
Mitochondrial Methylation in Type 2 Diabetes nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MT-CO1 binder may also engage these)

ProteinNameSimilarity
Q9T9X0 1.000 Q9T9X0 →
Q7GEN7 1.000 Q7GEN7 →
P92692 1.000 P92692 →
Q9T9W1 1.000 Q9T9W1 →
Q34800 1.000 Q34800 →
P00398 1.000 P00398 →
O03167 1.000 O03167 →
Q35536 1.000 Q35536 →
Q9ZXY2 1.000 Q9ZXY2 →
P34838 1.000 P34838 →
Q34345 1.000 Q34345 →
Q94WR7 1.000 Q94WR7 →
O79548 1.000 O79548 →
P48170 1.000 P48170 →
Q9ZZ64 1.000 Q9ZZ64 →
P00396 1.000 P00396 →
Q37705 1.000 Q37705 →
Q33820 1.000 Q33820 →
P18943 1.000 P18943 →
P34188 1.000 P34188 →
P24985 1.000 P24985 →
P00397 1.000 P00397 →
Q6EGH9 1.000 Q6EGH9 →
Q6EGH8 1.000 Q6EGH8 →
Q5Y4Q8 1.000 Q5Y4Q8 →
Q6EGI5 1.000 Q6EGI5 →
P41293 1.000 P41293 →
Q06473 1.000 Q06473 →
Q1HKA1 1.000 Q1HKA1 →
P24983 1.000 P24983 →