Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23402139 | 0.87 | SMN1; SMN2 (0.64) | GAASMN1; SMN2L3MBTL1RAB9AKAT8 | |
| SCHEMBL23401905 | 0.75 | GAA (0.51) | GAASMN1; SMN2L3MBTL1RAB9AMAPT | |
| SCHEMBL23400874 | 0.73 | SMN1; SMN2 (0.68) | GAASMN1; SMN2L3MBTL1RAB9AKAT8 | |
| SCHEMBL23402829 | 0.72 | SMN1; SMN2 (0.51) | GAASMN1; SMN2L3MBTL1RAB9AKAT8 | |
| SCHEMBL23400671 | 0.71 | ALDH1A1 (0.50) | GAAL3MBTL1KAT8MAPTALDH1A1 | |
| SCHEMBL23399905 | 0.70 | SMN1; SMN2 (0.49) | GAASMN1; SMN2L3MBTL1RAB9AKAT8 | |
| SCHEMBL23399289 | 0.70 | SMN1; SMN2 (0.59) | GAASMN1; SMN2L3MBTL1RAB9AKAT8 | |
| SCHEMBL23401829 | 0.70 | GAA (0.73) | GAASMN1; SMN2L3MBTL1RAB9AKAT8 | |
| SCHEMBL28299107 | 0.69 | GAA (0.58) | GAASMN1; SMN2L3MBTL1RAB9AKAT8 | |
| SCHEMBL23401447 | 0.69 | SMN1; SMN2 (0.48) | GAASMN1; SMN2L3MBTL1RAB9AKAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924562-A2 | PYRAZOLONE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025880-A2 | PYRAZOLONE DERIVATIVES AS 11-BETA HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |