Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | POLA1 | P09884 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29011061 | 0.90 | GRIN1 (0.52) | NPC1L1LMNAGPBAR1HSD17B10TDP1 | |
| SCHEMBL2637544 | 0.86 | NPC1L1 (0.66) | NPC1L1LMNAMEN1KMT2APOLA1 | |
| SCHEMBL2637542 | 0.86 | NPC1L1 (0.66) | NPC1L1LMNAMEN1KMT2APOLA1 | |
| SCHEMBL11793322 | 0.84 | OSBP (0.60) | NPC1L1GRIN1GRIN2AGRIN2BVDR | |
| SCHEMBL11793318 | 0.84 | OSBP (0.60) | NPC1L1GRIN1GRIN2AGRIN2BVDR | |
| SCHEMBL27568442 | 0.82 | NPC1L1 (0.47) | NPC1L1LMNAGPBAR1HSD17B10TDP1 | |
| SCHEMBL9117647 | 0.82 | LMNA (0.52) | NPC1L1LMNAGPBAR1HSD17B10TDP1 | |
| SCHEMBL29716344 | 0.81 | GRIN1 (0.45) | NPC1L1LMNAGPBAR1HSD17B10TDP1 | |
| SCHEMBL29696216 | 0.79 | NPC1L1 (0.41) | NPC1L1LMNAGPBAR1HSD17B10TDP1 | |
| SCHEMBL7630863 | 0.78 | GPBAR1 (0.70) | LMNAGPBAR1HSD17B10TDP1EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648223-A4 | NPC1L1 (NPC3) AND METHODS OF USE THEREOF | SCHERING CORP (US) | 2008-02-27 | — | — | EP | disclosed |
| EP-1680189-A2 | COMBINATIONS OF LIPID MODULATING AGENTS AND SUBSTITUTED AZETIDINONES AND TREATMENTS FOR VASCULAR CONDITIONS | SCHERING CORPORATION (US) | 2006-07-19 | — | — | EP | disclosed |
| EP-1648223-A1 | NPC1L1 (NPC3) AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2006-04-26 | — | — | EP | disclosed |
| EP-1601669-A1 | SUBSTITUTED AZETIDINONE COMPOUNDS, FORMULATIONS AND USES THEREOF FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | SCHERING CORPORATION (US) | 2005-12-07 | — | — | EP | disclosed |
| WO-2005046797-A2 | COMBINATIONS OF LIPID MODULATING AGENTS AND SUBSTITUTED AZETIDINONES AND TREATMENTS FOR VASCULAR CONDITIONS | SCHERING CORPORATION (US) | 2005-05-26 | — | — | WO | disclosed |
| WO-2005015988-A1 | NPC1L1 (NPC3) AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2004081003-A1 | SUBSTITUTED AZETIDINONE COMPOUNDS, FORMULATIONS AND USES THEREOF FOR THE TREATMENT OF HYPERCHOLETEROLEMIA | SCHERING CORPORATION (US) | 2004-09-23 | — | — | WO | disclosed |
| WO-2002058733-A9 | COMBINATIONS OF BILE ACID SEQUESTRANT(S) AND STEROL ABSORPTION INHIBITOR(S) AND TREATMENTS FOR VASCULAR INDICATIONS | SCHERING CORP (US) | 2003-03-06 | — | — | WO | disclosed |