Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.49 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.49 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.39 |
| ▸ | GLRB | P48167 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4121020 | 0.86 | TXNRD1 (0.52) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL4122724 | 0.75 | PDE7A (0.47) | MAPTNPSR1GAAMEN1KMT2A | |
| SCHEMBL4123964 | 0.73 | SLC6A2 (0.44) | MAPTALDH1A1NPSR1GAAHTT | |
| SCHEMBL4121656 | 0.73 | KMT2A (0.42) | MAPTALDH1A1GAAHTTMEN1 | |
| SCHEMBL4122654 | 0.72 | MEN1 (0.46) | MAPTALDH1A1GAAHTTMEN1 | |
| SCHEMBL5059416 | 0.71 | GLRA3 (0.43) | GLRA3GLRBCA1CA2 | |
| SCHEMBL1032814 | 0.70 | TXNRD1 (1.00) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL4128042 | 0.69 | MEN1 (0.43) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL4113997 | 0.69 | MEN1 (0.53) | ALDH1A1HTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4122737 | 0.69 | SMN1; SMN2 (0.43) | MAPTALDH1A1GAAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890993-A2 | BENZOIC ACID DERIVATIVES THAT ARE MODULATORS OR ANTAGONISTS OF GLYR | AstraZeneca AB (SE) | 2008-02-27 | — | — | EP | claimed |
| WO-2006121390-A2 | BENZOIC ACID DERIVATIVES THAT ARE MODULATORS OR AGONISTS OF GLYR | ASTRAZENECA AB (SE) | 2006-11-16 | — | — | WO | claimed |