Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11085764 | 0.77 | — | — | |
| SCHEMBL1666672 | 0.75 | — | — | |
| SCHEMBL5694090 | 0.73 | GDA (0.46) | — | |
| SCHEMBL12262030 | 0.67 | — | — | |
| SCHEMBL1836384 | 0.67 | KDR (0.36) | ALDH1A1 | |
| SCHEMBL8080125 | 0.65 | ADORA2A (0.35) | ADORA2A | |
| SCHEMBL1434439 | 0.65 | PNP (0.44) | — | |
| SCHEMBL706303 | 0.65 | PNP (0.44) | — | |
| SCHEMBL1367997 | 0.64 | PDPK1 (0.31) | ALDH1A1 | |
| SCHEMBL13863 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120029181-A1 | SYNTHESIS OF 5-AZACYTIDINE | PHARMION LLC (US) | 2012-02-02 | — | — | US | disclosed |
| US-8058424-B2 | Synthesis of 5-azacytidine | PHARMION LLC (US) | 2011-11-15 | — | — | US | disclosed |
| US-20110092694-A1 | SYNTHESIS OF 5-AZACYTIDINE | PHARMION LLC | 2011-04-21 | — | — | US | disclosed |
| US-7858774-B2 | Coupling silylated 5-azacytosine to a protected ribofuranose using trimethylsilyl trifluoromethane catalyst; cooling, accumulation by filtration, quenching, solvent extraction | PHARMION LLC (US) | 2010-12-28 | — | — | US | disclosed |
| US-20090005551-A1 | SYNTHESIS OF 5-AZACYTIDINE | CELGENE INTERNATIONAL SARL (CH) | 2009-01-01 | — | — | US | disclosed |
| US-20060247432-A1 | Synthesis of 5-Azacytidine | CELGENE INTERNATIONAL SARL (CH) | 2006-11-02 | — | — | US | disclosed |
| US-7038038-B2 | Synthesis of 5-azacytidine | PHARMION CORPORATION (US) | 2006-05-02 | — | — | US | disclosed |
| WO-2004082618-A2 | SYNTHESIS OF 5-AZACYTIDINE | ASH STEVENS INC (US) | 2004-09-30 | — | — | WO | disclosed |
| US-20040186283-A1 | Synthesis of 5-azacytidine | CELGENE INTERNATIONAL SARL (CH) | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092694-A1 | SYNTHESIS OF 5-AZACYTIDINE | TYMS, DNMT1, TET1 | ALDH1A1 2154/4885ADORA2A 1227/4885ADORA2B 1650/4885 |
| US-20120029181-A1 | SYNTHESIS OF 5-AZACYTIDINE | TYMS, DNMT1, TET1 | ALDH1A1 2154/4885ADORA2A 1227/4885ADORA2B 1650/4885 |
| US-20060247432-A1 | Synthesis of 5-Azacytidine | TYMS, DNMT1, TET1 | ALDH1A1 2154/4885ADORA2A 1227/4885ADORA2B 1650/4885 |
| US-20040186283-A1 | Synthesis of 5-azacytidine | DNMT1, TYMS, TET1 | ALDH1A1 2092/4885ADORA2A 1369/4885ADORA2B 2031/4885 |
| US-20090005551-A1 | SYNTHESIS OF 5-AZACYTIDINE | TYMS, DNMT1, TET1 | ALDH1A1 2154/4885ADORA2A 1227/4885ADORA2B 1650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.