Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5055625 | 0.85 | CHEK1 (0.39) | CHEK1CDK7MMP13 | |
| SCHEMBL5055588 | 0.84 | CHEK1 (0.38) | CHEK1CDK7MMP13 | |
| SCHEMBL5051856 | 0.79 | CHEK1 (0.41) | CHEK1CDK7MMP13 | |
| SCHEMBL5061404 | 0.78 | CHEK1 (0.58) | HPNCHEK1CDK7 | |
| SCHEMBL27708367 | 0.74 | CHEK1 (0.43) | HPNCHEK1CDK7 | |
| SCHEMBL5051829 | 0.72 | CHEK1 (0.50) | CHEK1CDK7 | |
| SCHEMBL5054018 | 0.70 | KDM4C (0.37) | CHEK1 | |
| SCHEMBL5054001 | 0.69 | KDM4C (0.36) | — | |
| SCHEMBL20266986 | 0.68 | HRH3 (0.52) | — | |
| SCHEMBL23535811 | 0.66 | BRD4 (0.41) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004259-A1 | Inhibitors of Checkpoint Kinases | MERCK & CO., INC. | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004259-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, BUB1B | HPN 3776/4885BRD4 336/4885PDCD1 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.