Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13677587 | 0.90 | KDM4E (0.47) | KDM4ECHEK1HRH3 | |
| SCHEMBL12643242 | 0.90 | KDM4E (0.47) | KDM4ECHEK1HRH3 | |
| SCHEMBL2037624 | 0.90 | KDM4E (0.47) | KDM4ECHEK1HRH3 | |
| SCHEMBL5066850 | 0.88 | SCN9A (0.48) | HCRTR1KDM4EIDH2CHEK1HCRTR2 | |
| SCHEMBL5164315 | 0.86 | IDH2 (0.46) | HCRTR1KDM4EIDH2CHEK1HCRTR2 | |
| SCHEMBL13997115 | 0.85 | CHEK1 (0.48) | HCRTR1KDM4EIDH2CHEK1 | |
| Hydrochloric Acid SCHEMBL5059305 | 0.84 | CHEK1 (0.47) | HCRTR1KDM4EIDH2CHEK1 | |
| SCHEMBL2036333 | 0.84 | KDM4E (0.51) | KDM4ECHEK1 | |
| SCHEMBL2031893 | 0.83 | CHEK1 (0.49) | CHEK1HRH3 | |
| SCHEMBL2036172 | 0.82 | KDM4E (0.41) | HCRTR1KDM4EHCRTR2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | ICOS CORPORATION (US) | 2008-12-25 | — | — | US | claimed |
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | ICOS CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | ICOS CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | ICOS CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| CN-101115727-A | Compounds for inhibition of CHK1 | ICOS CORP (US) | 2008-01-30 | — | — | CN | disclosed |
| US-20070185013-A1 | Use of chk1 inhibitors to control cell proliferation | ICOS CORPORATION (US) | 2007-08-09 | — | — | US | disclosed |
| EP-1778648-A2 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | ICOS Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006021002-A2 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | ICOS CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185013-A1 | Use of chk1 inhibitors to control cell proliferation | CHEK1, CHEK2, CDC25C | HCRTR1 3905/4885KDM4E 1263/4885IDH2 917/4885 |
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | CHEK1, PCNA, CHEK2 | HCRTR1 4805/4885KDM4E 2395/4885IDH2 742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.