Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.46 |
| ▸ | FECH | P22830 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5059305 | 0.99 | CHEK1 (0.47) | CHEK1HCRTR1FECHKCNH2KDM4E | |
| SCHEMBL13997114 | 0.91 | IDH2 (0.47) | CHEK1FECHKCNH2IDH2SCN9A | |
| Hydrochloric Acid SCHEMBL5063346 | 0.90 | IDH2 (0.47) | CHEK1FECHKCNH2IDH2SCN9A | |
| SCHEMBL2033685 | 0.90 | CHEK1 (0.53) | CHEK1FECHKCNH2KDM4ESCN9A | |
| SCHEMBL16416700 | 0.86 | CHEK1 (0.49) | CHEK1FECHKCNH2KDM4ESCN9A | |
| SCHEMBL5163078 | 0.86 | CHEK1 (0.49) | CHEK1FECHKCNH2IDH2SCN9A | |
| SCHEMBL5163065 | 0.86 | CHEK1 (0.49) | CHEK1FECHKCNH2IDH2SCN9A | |
| SCHEMBL5163178 | 0.86 | CHEK1 (0.49) | CHEK1FECHKCNH2IDH2SCN9A | |
| SCHEMBL5063309 | 0.85 | HCRTR1 (0.48) | CHEK1HCRTR1KDM4EIDH2 | |
| SCHEMBL5063318 | 0.84 | HCRTR1 (0.45) | CHEK1HCRTR1FECHKCNH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | ICOS CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | ICOS CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| US-20070185013-A1 | Use of chk1 inhibitors to control cell proliferation | ICOS CORPORATION (US) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185013-A1 | Use of chk1 inhibitors to control cell proliferation | CHEK1, CHEK2, CDC25C | CHEK1 1/4885HCRTR1 3905/4885FECH 1861/4885 |
| US-20080318974-A1 | Compounds Useful for Inhibiting Chk1 | CHEK1, PCNA, CHEK2 | CHEK1 1/4885HCRTR1 4805/4885FECH 2044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.