Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | SYK | P43405 | 6/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.45 |
| ▸ | ITK | Q08881 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | CDK1 | P06493 | 4/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | AURKA | O14965 | 4/20 | 0.45 |
| ▸ | PLK4 | O00444 | 3/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.45 |
| ▸ | PAK4 | O96013 | 3/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.45 |
| ▸ | PRKCG | P05129 | 3/20 | 0.45 |
| ▸ | INSR | P06213 | 3/20 | 0.45 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1474744 | 0.92 | EGFR (0.54) | EGFRSYKNTRK1ITKJAK2 | |
| SCHEMBL5059058 | 0.84 | CDK1 (0.51) | EGFRSYKNTRK1ITKJAK2 | |
| SCHEMBL1474611 | 0.81 | SYK (0.57) | EGFRSYKNTRK1ITKJAK2 | |
| SCHEMBL1474672 | 0.80 | JAK3 (0.60) | EGFRSYKNTRK1ITKJAK2 | |
| SCHEMBL1607189 | 0.80 | JAK3 (0.60) | EGFRSYKNTRK1ITKJAK2 | |
| SCHEMBL1474409 | 0.77 | STK17A (0.57) | EGFRSYKNTRK1ITKJAK2 | |
| SCHEMBL1275642 | 0.77 | SYK (0.72) | EGFRSYKNTRK1ITKJAK2 | |
| SCHEMBL1474614 | 0.76 | SYK (0.56) | EGFRSYKNTRK1ITKJAK2 | |
| SCHEMBL1606869 | 0.75 | CDK1 (0.57) | EGFRSYKNTRK1ITKJAK2 | |
| SCHEMBL1475626 | 0.75 | CDK1 (0.57) | EGFRSYKNTRK1ITKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079907-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | claimed |