Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.57 |
| ▸ | PRKDC | P78527 | 9/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.45 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL408618 | 0.97 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL200349 | 0.87 | NUDT14 (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL30387175 | 0.87 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| Hydrochloric Acid SCHEMBL29439185 | 0.86 | NUDT14 (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL15613778 | 0.84 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL3782102 | 0.84 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL11325 | 0.84 | PIK3CG (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL3715031 | 0.84 | SRC (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL20793881 | 0.82 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL3605078 | 0.82 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004654-A2 | KINASE ANTAGONISTS | The Regents of the University of California (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007114926-A2 | KINASE ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-11 | — | — | WO | disclosed |