Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 14/20 | 0.85 |
| ▸ | RBPJ | Q06330 | 4/20 | 0.85 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.85 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.85 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.85 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.85 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.85 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.85 |
| ▸ | NOTCH3 | Q9UM47 | 10/20 | 0.70 |
| ▸ | NOTCH2 | Q04721 | 1/20 | 0.57 |
| ▸ | NOTCH4 | Q99466 | 1/20 | 0.57 |
| ▸ | CCKBR | P32239 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18634631 | 0.92 | NOTCH1 (1.00) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287889 | 0.92 | NOTCH1 (1.00) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287605 | 0.92 | NOTCH1 (1.00) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL5839931 | 0.92 | NOTCH1 (1.00) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3289687 | 0.92 | NOTCH1 (1.00) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL16273076 | 0.91 | NOTCH1 (0.91) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287247 | 0.90 | NOTCH1 (0.84) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL18634756 | 0.86 | NOTCH1 (1.00) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3290428 | 0.86 | NOTCH1 (1.00) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287265 | 0.85 | NOTCH1 (0.82) | NOTCH1RBPJPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171735-A1 | Coupling a solid phase bound succinic acid derivative by amidation to an aminolactam (1-methyl,2-oxo,3-amino,4-phenyl-2H-1,4-benzodiazepine) mediated by a uronium salt and a carbodiimide; releasing using dilute trifluoroacetic acid in dichloromethane; purified by chromatography; Alzeimer's; Down's | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171735-A1 | Coupling a solid phase bound succinic acid derivative by amidation to an aminolactam (1-methyl,2-oxo,3-amino,4-phenyl-2H-1,4-benzodiazepine) mediated by a uronium salt and a carbodiimide; releasing using dilute trifluoroacetic acid in dichloromethane; purified by chromatography; Alzeimer's; Down's | PSEN1, APP, GABRA6 | NOTCH1 528/4885RBPJ 3834/4885PSEN1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.