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GABRA6

Gamma-aminobutyric acid receptor subunit alpha-6 · Q16445 · GABRA6 on Sugi Atlas →

127,988 patent compounds predicted against GABRA6, 65,557 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15406 SCHEMBL15406 0.61 20/20
Fipronil Fipronil (SCHEMBL15088) 0.59 20/20
SCHEMBL41972 SCHEMBL41972 0.59 20/20
Fipronil Fipronil (SCHEMBL44222) 0.59 20/20
Ethiprole Ethiprole (SCHEMBL27048) 0.56 20/20
SCHEMBL25897 SCHEMBL25897 0.51 20/20
SCHEMBL33214 SCHEMBL33214 0.52 19/20
SCHEMBL26584 SCHEMBL26584 0.51 19/20
SCHEMBL9107 SCHEMBL9107 0.56 12/20
SCHEMBL8532 SCHEMBL8532 1.00 11/20
Flumazenil Flumazenil (SCHEMBL79030) 1.00 10/20
SCHEMBL9035 SCHEMBL9035 0.56 10/20
SCHEMBL8632 SCHEMBL8632 0.54 10/20
SCHEMBL8670 SCHEMBL8670 0.57 9/20
SCHEMBL8856 SCHEMBL8856 0.53 9/20
SCHEMBL9273 SCHEMBL9273 0.53 9/20
SCHEMBL8931 SCHEMBL8931 0.51 9/20
SCHEMBL8932 SCHEMBL8932 0.51 9/20
Iomazenil Iomazenil (SCHEMBL41658) 0.62 8/20
SCHEMBL9163 SCHEMBL9163 0.58 8/20

Clinical trials — most relevant to GABRA6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Computational Assessment of GABA Receptor Modulation in PTSD PHASE4RECRUITING
Safety of Ramelteon in Elderly Subjects PHASE4COMPLETED
The Effects of Levetiracetam on Alcohol Dependent Subjects PHASE4COMPLETED
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence. PHASE4COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia PHASE3COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia PHASE2COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia PHASE2COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy PHASE1/PHASE2WITHDRAWN
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome PHASE2RECRUITING
PET Imaging of Brain Peripheral Benzodiazepine Receptors PHASE1COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28 PHASE1COMPLETED
Physiologic Effects of Topiramate on Cognition PHASE1COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T EARLY_PHASE1UNKNOWN
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
GABA Biomarkers in Dravet Syndrome nanRECRUITING
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy nanUNKNOWN
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy nanENROLLING_BY_INVITATION
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA) nanCOMPLETED
Exploring the Role of the Prefrontal Cortex in Decision-Making nanRECRUITING
Assessment of Peripheral GABA Receptors for Local Pain Relief nanUNKNOWN
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. nanCOMPLETED
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic Cholecystectomy nanNOT_YET_RECRUITING
Mechanisms of Human Plasticity in the Human System nanCOMPLETED
Effects of Flumazenil on Brain Excitability nanCOMPLETED
Effect of Gabapentin on GABA Concentration and Emotional Processing nanCOMPLETED
Remifentanil and Remimazolam to Limit Patient Movement nanRECRUITING
Brain Changes in Patients With Focal Hand Dystonia nanCOMPLETED
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a GABRA6 binder may also engage these)

ProteinNameSimilarity
P16305 — 1.000 P16305 →
P30191 — 0.998 P30191 →
Q90845 — 0.995 Q90845 →
P10064 — 0.987 P10064 →
P26049 — 0.986 P26049 →
GABRA3 Gamma-aminobutyric acid receptor subunit alpha-3 0.984 landscape →
P20236 — 0.984 P20236 →
P28471 — 0.969 P28471 →
P24045 — 0.969 P24045 →
P20237 — 0.968 P20237 →
P23574 — 0.967 P23574 →
P34904 — 0.966 P34904 →
GABRA4 Gamma-aminobutyric acid receptor subunit alpha-4 0.966 landscape →
P22300 — 0.965 P22300 →
Q9D6F4 — 0.964 Q9D6F4 →
Q9R0Y8 — 0.964 Q9R0Y8 →
GABRG2 Gamma-aminobutyric acid receptor subunit gamm 0.962 landscape →
GABRG1 Gamma-aminobutyric acid receptor subunit gamm 0.961 landscape →
P22723 — 0.959 P22723 →
P18508 — 0.958 P18508 →
Q5REA1 — 0.956 Q5REA1 →
Q08E50 — 0.954 Q08E50 →
P19150 — 0.953 P19150 →
P19969 — 0.953 P19969 →
Q5R6B2 — 0.952 Q5R6B2 →
GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 0.951 landscape →
P08219 — 0.951 P08219 →
GABRA5 Gamma-aminobutyric acid receptor subunit alpha-5 0.951 landscape →
Q4R534 — 0.951 Q4R534 →
P62813 — 0.950 P62813 →