Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 19/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | GLA | P06280 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | STAT6 | P42226 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5058798 | 0.95 | TOP1 (0.77) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL6086820 | 0.92 | TOP1 (0.68) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL6087893 | 0.90 | TOP1 (0.75) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL6087342 | 0.89 | TOP1 (0.77) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL5065698 | 0.89 | TOP1 (0.88) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL6087767 | 0.89 | TOP1 (0.76) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL2929566 | 0.88 | TOP1 (0.80) | TOP1KDM4ERAB9ABLMRECQL | |
| SCHEMBL26514712 | 0.88 | TOP1 (0.80) | TOP1KDM4ERAB9ABLMRECQL | |
| Namitecan SCHEMBL24685130 | 0.87 | TOP1 (0.85) | TOP1KDM4ERAB9ABLMRECQL | |
| Namitecan SCHEMBL29482428 | 0.87 | TOP1 (0.85) | TOP1KDM4ERAB9ABLMRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004083365-A9 | COMPOUNDS AND THEIR USE FOR SPECIFIC AND SIMULTANEOUS INHIBITION OF GENES INVOLVED IN DISEASES AND RELATED DRUGS | INST NAT SANTE RECH MED (FR) | 2008-07-10 | — | — | WO | claimed |
| US-20080108581-A1 | Compounds and Their Use for Specific and Simultaneous Inhibition of Genes Involved In Diseases and Related Drugs | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (I.N.S.E.R.M.) (FR) | 2008-05-08 | — | — | US | claimed |
| WO-2004083365-A9 | COMPOUNDS AND THEIR USE FOR SPECIFIC AND SIMULTANEOUS INHIBITION OF GENES INVOLVED IN DISEASES AND RELATED DRUGS | INST NAT SANTE RECH MED (FR) | 2008-07-10 | — | — | WO | disclosed |
| US-20080108581-A1 | Compounds and Their Use for Specific and Simultaneous Inhibition of Genes Involved In Diseases and Related Drugs | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (I.N.S.E.R.M.) (FR) | 2008-05-08 | — | — | US | disclosed |
| EP-1606405-A2 | COMPOUNDS AND THEIR USE FOR SPECIFIC AND SIMULTANEOUS INHIBITION OF GENES INVOLVED IN DISEASES AND RELATED DRUGS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004083365-A2 | COMPOUNDS AND THEIR USE FOR SPECIFIC AND SIMULTANEOUS INHIBITION OF GENES INVOLVED IN DISEASES AND RELATED DRUGS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2004-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108581-A1 | Compounds and Their Use for Specific and Simultaneous Inhibition of Genes Involved In Diseases and Related Drugs | TOP2A, TOP1, TOP2B | TOP1 2/4885KDM4E 2719/4885RAB9A 4620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.