Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175518 | 0.86 | AOC3 (0.55) | ADRB2ADRB1CYP2D6NFKB1HIF1A | |
| SCHEMBL5067518 | 0.83 | MEN1 (0.40) | HIF1AMEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL5065804 | 0.81 | RIPK1 (0.53) | AOC3MEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL1529441 | 0.81 | RIPK1 (0.53) | AOC3MEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL5069200 | 0.81 | RIPK1 (0.53) | AOC3MEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL16673918 | 0.78 | AOC3 (0.42) | ADRB2ADRB1CYP2D6NFKB1HIF1A | |
| SCHEMBL5065045 | 0.77 | AOC3 (0.43) | AOC3MEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL1529933 | 0.76 | AOC3 (0.43) | ADRB2ADRB1CYP2D6NFKB1HIF1A | |
| SCHEMBL5069163 | 0.76 | ADRB3 (0.41) | ADRB2ADRB1CYP2D6MEN1KMT2A | |
| SCHEMBL16673586 | 0.75 | AOC3 (0.39) | ADRB2ADRB1CYP2D6NFKB1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | HEERDING DIRK A | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | ADRB2 4820/4885ADRB1 4693/4885CYP2D6 3974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.