Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 11/20 | 0.55 |
| ▸ | AKT1 | P31749 | 6/20 | 0.55 |
| ▸ | RPS6KA1 | Q15418 | 4/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068446 | 0.83 | RPS6KA5 (0.53) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 | |
| SCHEMBL4064963 | 0.83 | RPS6KA5 (0.55) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 | |
| SCHEMBL4065881 | 0.83 | RPS6KA5 (0.60) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL5062967 | 0.82 | RPS6KA5 (0.67) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 | |
| SCHEMBL4566808 | 0.80 | RPS6KA5 (0.67) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| SCHEMBL4240141 | 0.79 | RPS6KA5 (0.59) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL5058554 | 0.78 | SLC2A1 (0.52) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 | |
| SCHEMBL5058506 | 0.77 | RPS6KA5 (0.65) | RPS6KA5AKT1RPS6KA1ROCK1PRKACA | |
| Trifluoroacetic Acid SCHEMBL4389888 | 0.77 | AKT1 (0.53) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 | |
| SCHEMBL4066679 | 0.77 | RPS6KA5 (0.55) | RPS6KA5AKT1RPS6KA1ROCK1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | claimed |
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | RPS6KA5 156/4885AKT1 5/4885RPS6KA1 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.