Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MITF | O75030 | 2/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068232 | 0.84 | KDM4E (0.36) | POLBALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL14319941 | 0.83 | POLB (0.41) | AKR1C3AKR1C2POLBCCR2ALDH1A1 | |
| SCHEMBL20846497 | 0.73 | KDM4E (0.63) | AKR1C3AKR1C2ALDH1A1KDM4ETDP1 | |
| SCHEMBL23832437 | 0.73 | CYP2A6 (0.43) | MAPTHTTKDM4ELMNATDP1 | |
| SCHEMBL30199419 | 0.73 | CYP2A6 (0.43) | MAPTHTTKDM4ELMNATDP1 | |
| SCHEMBL4925604 | 0.72 | MAPT (0.50) | ALDH1A1MAPTSMN1; SMN2HPGDLMNA | |
| SCHEMBL812098 | 0.71 | MAOB (0.44) | ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL16720902 | 0.71 | AKR1C3 (0.48) | AKR1C3AKR1C2POLBALDH1A1MAPT | |
| SCHEMBL30439601 | 0.70 | CYP2A6 (0.45) | MAPTHTTKDM4ELMNATDP1 | |
| SCHEMBL23832432 | 0.70 | CYP2A6 (0.45) | MAPTHTTKDM4ELMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653947-B1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVES AS ESTROGENIC AGENTS | WYETH CORP (US) | 2008-01-16 | — | — | EP | disclosed |
| US-20070249703-A1 | (Hydroxyphenyl)-1H-Indole-3-Carbaldehyde Oxime Derivatives As Estrogenic Agents | WYETH (US) | 2007-10-25 | — | — | US | disclosed |
| US-7250440-B2 | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents | WYETH (US) | 2007-07-31 | — | — | US | disclosed |
| US-20050059723-A1 | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents | WYETH (US) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249703-A1 | (Hydroxyphenyl)-1H-Indole-3-Carbaldehyde Oxime Derivatives As Estrogenic Agents | ESR1, ESR2, GPER1 | AKR1C3 295/4885AKR1C2 418/4885POLB 4557/4885 |
| US-20050059723-A1 | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents | ESR1, ESR2, GPER1 | AKR1C3 295/4885AKR1C2 418/4885POLB 4557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.