Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.44 |
| ▸ | PRKDC | P78527 | 7/20 | 0.44 |
| ▸ | SRC | P12931 | 6/20 | 0.37 |
| ▸ | ABL1 | P00519 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.34 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21364711 | 0.80 | MAP4K4 (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL30387451 | 0.79 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL30387716 | 0.78 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL19414398 | 0.77 | MAP4K4 (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL145785 | 0.77 | SRC (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL21048477 | 0.74 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL15276905 | 0.74 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL11149 | 0.74 | BTK (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL17626717 | 0.73 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL20793606 | 0.73 | KDM4E (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004654-A2 | KINASE ANTAGONISTS | The Regents of the University of California (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007114926-A2 | KINASE ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-11 | — | — | WO | disclosed |