Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.47 |
| ▸ | PRKDC | P78527 | 7/20 | 0.47 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.47 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22692856 | 0.86 | ERBB2 (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL20093445 | 0.84 | EGFR (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL19414295 | 0.83 | SRC (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL200349 | 0.83 | NUDT14 (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL30387716 | 0.82 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| Hydrochloric Acid SCHEMBL29439185 | 0.82 | NUDT14 (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL20093481 | 0.81 | KMO (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL13293328 | 0.80 | ERBB2 (0.56) | BTKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL19385334 | 0.78 | LCK (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL21386702 | 0.78 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9694011-B2 | Substituted pyrazolopyrimidines as kinases inhibitors | JIANGSU MEDOLUTION LTD (CN) | 2017-07-04 | — | — | US | disclosed |
| US-9694011-B2 | Substituted pyrazolopyrimidines as kinases inhibitors | JIANGSU MEDOLUTION LTD (CN) | 2017-07-04 | — | — | US | disclosed |
| US-9694011-B2 | Substituted pyrazolopyrimidines as kinases inhibitors | JIANGSU MEDOLUTION LTD (CN) | 2017-07-04 | — | — | US | disclosed |
| US-20160120868-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASES INHIBITORS | JIANGSU MEDOLUTION LTD. (CN) | 2016-05-05 | — | — | US | disclosed |
| US-20160120868-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASES INHIBITORS | JIANGSU MEDOLUTION LTD. (CN) | 2016-05-05 | — | — | US | disclosed |
| US-20160120868-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASES INHIBITORS | JIANGSU MEDOLUTION LTD. (CN) | 2016-05-05 | — | — | US | disclosed |
| EP-2999702-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASES INHIBITORS | Jiangsu Medolution Ltd. (CN) | 2016-03-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160120868-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASES INHIBITORS | BTK, LCK, ABL1 | PIK3CD 224/4885PIK3CA 55/4885PIK3CB 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.