Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Granisetron. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A known ✓ | P46098 | 12/20 | 0.96 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.96 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.96 |
| ▸ | HTR3B | O95264 | 1/20 | 0.96 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.96 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.96 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.96 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.96 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.96 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.87 |
| ▸ | TSHR | P16473 | 1/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Granisetron SCHEMBL5060939 | 0.99 | HTR3A (0.98) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Granisetron SCHEMBL33433 | 0.99 | HTR3A (0.98) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Granisetron SCHEMBL34177 | 0.99 | HTR3A (0.98) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Granisetron SCHEMBL30773918 | 0.99 | HTR3A (0.98) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Granisetron SCHEMBL34179 | 0.99 | HTR3A (0.98) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Granisetron SCHEMBL678018 | 0.98 | HTR3A (0.96) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Granisetron SCHEMBL16642163 | 0.98 | HTR3A (1.00) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Granisetron SCHEMBL445223 | 0.98 | HTR3A (1.00) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Granisetron SCHEMBL4890 | 0.98 | HTR3A (1.00) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Granisetron SCHEMBL34178 | 0.98 | HTR3A (1.00) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556135-B1 | TRANSDERMAL DELIVERY SYSTEM FOR ANTI-EMETIC MEDICATION | SYNERON MEDICAL LTD (IL) | 2017-09-27 | — | — | EP | disclosed |
| US-7415306-B2 | Transdermal delivery system for anti-emetic medication | TRANSPHARMA MEDICAL LTD. (IL) | 2008-08-19 | — | — | US | disclosed |
| US-20050260252-A1 | Transdermal delivery system for anti-emetic medication | CANDELA CORPORATION | 2005-11-24 | — | — | US | disclosed |
| EP-1556135-A2 | TRANSDERMAL DELIVERY SYSTEM FOR ANTI-EMETIC MEDICATION | Transpharma Medical Ltd. (IL) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004039427-A2 | TRANSDERMAL DELIVERY SYSTEM FOR ANTI-EMETIC MEDICATION | TRANSPHARMA MEDICAL LTD. (IL) | 2004-05-13 | — | — | WO | disclosed |