Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | EIF4E | P06730 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458654 | 0.86 | ALDH1A1 (0.41) | ALDH1A1LMNANOTUMCSNK2A2CSNK2B | |
| SCHEMBL16012996 | 0.82 | MKNK1 (0.46) | ALDH1A1LMNANOTUMCSNK2A2CSNK2B | |
| SCHEMBL5464890 | 0.82 | ALDH1A1 (0.42) | ALDH1A1LMNANOTUMDYRK1ATDP1 | |
| SCHEMBL5065405 | 0.79 | HSD17B10 (0.44) | ALDH1A1LMNANOTUMCSNK2A2CSNK2B | |
| SCHEMBL16371583 | 0.78 | DYRK1A (0.33) | DYRK1AIKBKBLIMK1EIF4EMKNK1 | |
| SCHEMBL16013396 | 0.77 | MKNK1 (0.48) | ALDH1A1LMNANOTUMKMT2AMKNK1 | |
| SCHEMBL5068984 | 0.77 | MKNK2 (0.42) | ALDH1A1LMNAIKBKBLIMK1EIF4E | |
| SCHEMBL24401465 | 0.75 | NOTUM (0.43) | ALDH1A1LMNANOTUMKMT2AMKNK1 | |
| SCHEMBL16013302 | 0.75 | MKNK1 (0.52) | ALDH1A1LMNANOTUMMKNK1 | |
| SCHEMBL5064699 | 0.74 | MKNK1 (0.40) | ALDH1A1NOTUMKMT2AMKNK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108495855-B | Fused thiazolopyrimidine derivatives as MNK inhibitors | 生命弧度公司 | 2022-05-31 | — | — | CN | disclosed |
| EP-3019505-A1 | SUBSTITUTED PYRAZOLO-PYRIDINAMINES | Bayer Pharma Aktiengesellschaft (DE) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015004024-A1 | SUBSTITUTED PYRAZOLO-PYRIDINAMINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-01-15 | — | — | WO | disclosed |
| US-20080269238-A1 | Thiazolopyrimidine Derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-10-30 | — | — | US | disclosed |
| US-20080269238-A1 | Thiazolopyrimidine Derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-10-30 | — | — | US | disclosed |
| US-20080269238-A1 | Thiazolopyrimidine Derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-10-30 | — | — | US | disclosed |
| EP-1731523-A1 | THIAZOLOPYRIMIDINE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2006-12-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269238-A1 | Thiazolopyrimidine Derivative | FGFR3, FGFR1, ERBB3 | ALDH1A1 1911/4885LMNA 4401/4885NOTUM 4612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.